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Belltown Spine & Wellness has helped thousands of people over the past 25 years regain their health and vitality in Seattle.

NEW PATIENT SPECIAL: FREE CONSULTATION & COMPUTERIZED POSTURAL SCAN!
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NEW PATIENT SPECIAL: FREE CONSULTATION & COMPUTERIZED POSTURAL SCAN!

Belltown Spine & Wellness Services

Belltown Spine & Wellness is an integrated health and wellness center that has helped thousands of people regain their health and vitality in the greater Seattle area. Services are customized and targeted for each individual's health goals.  

Dr. Scott Mindel, Seattle chiropractor and owner of Belltown Spine & Wellness, created the signature 4-step program that is specifically designed to help patients recover from chronic neck and back pain conditions along with using the latest rehabilitation techniques available today.

Corrective Chiropractic Care

Belltown Spine & Wellness practices the state-of-the-art Corrective Biophysics Technique using Mirror Image exercise, adjusting and postural traction to correct the spine, and posture deviations back towards normal alignment and balance. Founder, Dr. Scott Mindel's 4-step Method has helped his patients restore overall health for over two decades in Seattle.

Massage Therapy

Belltown Spine & Wellness offers different types of massage to best suit individual client needs and preferences, including deep tissue, Swedish, and Manual Ligament Therapy, sports massage, lymphatic drainage, Healing Touch, trigger point therapy, reflexology, craniosacral, intra-oral, and pre-natal massage.

Naturopathic Medicine & Acupuncture

Holistic medicine is a form of healing that considers the body, mind, spirit, and emotions in the quest for optimal health and wellness do one can achieve optimal health by gaining proper balance in life. Naturopathic medicine, acupuncture and chiropractors target the root cause of an issue as opposed to simply reducing or managing symptoms.

Weightloss & wellness

Belltown Weightloss & Wellness is a physician supervised 4-phase weight loss and complete lifestyle program. Your coach will help you lose weight, reach your ideal weight goal, and educate you on exactly what to eat to maintain your new weight and improved health to help you keep off the weight and continue living a healthier life.
STOP WAITING. SCHEDULE YOUR FREE CONSULTATION TODAY!

Our Seattle Chiropractors & Doctor

Dr. Scott Mindel

Dr. Scott Mindel

Doctor of Chiropractic
Dr. Gion Monn

Dr. Gion Monn

Doctor of Chiropractic
Dr. Julie Sutton

Dr. Julie Sutton

Naturopathic Doctor / Licensed Acupuncturist
Dr. Nolan Deatherage

Dr. Nolan Deatherage

Doctor of Chiropractic

Diet-induced changes in the gut's bacterial ecosystem can alter susceptibility to an autoinflammatory bone disease by modifying the immune response, St. Jude Children's

Research Hospital scientists reported. The findings appeared September 28 as an advanced online publication of the scientific journal Nature.

 

The research provides insight into how the thousands of bacteria and other microorganisms that live in the intestines affect health. The microbes make up the intestinal microbiome, a diverse evolving ecosystem that aids digestion and helps to educate the immune cells that guard against infection. Growing evidence suggests that changes in the microbiome composition may contribute to development of diseases ranging from cancer to chronic inflammatory disorders such as multiple sclerosis. The mechanisms involved, however, were poorly understood.

"These results are exciting because they help to explain how environmental factors like diet can influence susceptibility to autoinflammatory diseases," said the study's corresponding author Thirumala-Devi Kanneganti, PhD, a member of the St. Jude Department of Immunology. "While multiple lines of evidence have suggested that diet can impact human disease, the scientific mechanism involved was a mystery. Our results demonstrate that diet can influence immune-mediated disorders by shaping the composition of the gut microbiome, which our findings suggest play a role in immune regulation."

The study was done in a mouse model of the devastating inflammatory childhood bone disorder chronic recurrent multifocal osteomyelitis (CRMO). The mice carry a mutation in the Pstpip2 gene that leads to osteomyelitis early in life.

Researchers showed that changing the nutritional composition of the animals' diets led to marked increases and decreases of certain intestinal bacteria. Affected bacteria included Prevotella, which have been implicated in causing osteomyelitis, arthritis, periodontal disease, and other inflammatory disorders in humans.

A diet that limited intestinal Prevotella growth also protected the mutant mice from developing osteomyelitis. The same diet was associated with reduced production of the immune molecule interleukin-1beta (IL-1beta) that promotes inflammation. Earlier work from Kanneganti's laboratory demonstrated that IL-1beta fueled osteomyelitis in the mutant mice. In this study, researchers reported that dietary changes impacted the supply of IL-1beta in immune cells called neutrophils.

To confirm the connection between the intestinal microbiome and osteomyelitis, researchers treated mice that were fed the disease-promoting diet with a cocktail of broad-spectrum antibiotics. Treatment was followed by a reduction in Prevotella as well as intestinal levels of IL-1beta. In addition, fewer mice developed osteomyelitis.

In a series of probiotic experiments, investigators demonstrated that transplanting the intestinal microbiome from healthy mice protected the at-risk, mutant mice from osteomyelitis. Probiotics are bacteria and other microorganisms with a demonstrated health benefit. "The results suggest probiotics might provide a more targeted method for suppressing production of IL-1beta and protecting against autoinflammatory diseases," said first author John Lukens, PhD, a St. Jude postdoctoral fellow.

The research also provided key details about IL-1beta production and regulation in neutrophils, which are part of the body's first line of defense. Investigators identified the two enzymes capable of converting the immune molecule from its inactive form to the pro-inflammatory IL-1beta. The enzymes are caspases 1 and 8. Deleting both enzymes led to a dramatic decline in IL-1beta in the susceptible mice and protected the animals from osteomyelitis.

The study's other authors are Prajwal Gurung, Peter Vogel, Gordon Johnson, Robert Carter, Daniel McGoldrick, Srinivasa Rao Bandi, and Christopher Calabrese, all of St. Jude; and Lieselotte Vande Walle and Mohamed Lamkanfi, of Ghent University, Ghent, Belgium.

The research was funded in part by a grant (AR056296) from the National Institute of Arthritis and Musculoskeletal and Skin Diseases, part of the National Institutes of Health (NIH); a grant (CA163507) from the National Cancer Institute, part of the NIH; a grant (AI101935) from the National Institute of Allergy and Infectious Diseases, part of the NIH; and ALSAC.

Source: St. Jude Children's Research Hospital, stjude.org

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